Discovering and targeting unprecedented mitochondrial vulnerabilities against multiple myeloma

Basic Information

Funding Cycle : 2021-2022
Name : Simone Cenci
Type of Award : Translational Research Award
Home Institution : Ospedale San Raffaele, Milan, Italy


This research aims to target mitochondrial vulnerabilities in multiple myeloma (MM) by focusing on ClpP, a mitochondrial protease highly expressed in MM cells. Leveraging ClpP’s importance for MM cell survival, the study seeks to understand its function and identify novel mitochondrial vulnerabilities. Using functional geno-proteomics and genetic screening, the research aims to achieve two main objectives: 1) Understanding and targeting ClpP to devise new therapies, and 2) High-throughput screening to identify additional mitochondrial vulnerabilities in MM. Through these approaches, the study aims to uncover novel targets for more effective MM treatments, potentially leading to improved outcomes for patients with this incurable disease.

Why Become a Member

The International Myeloma Society is a professional, scientific, and medical society established to bring together clinical and experimental scientists involved in the study of myeloma. The purpose of this society is to promote research, education, clinical studies (including diagnosis and treatment), workshops, conferences, and symposia on all aspects of multiple myeloma worldwide.

The IMS is a membership organization comprised of basic research scientists, and clinical investigators in the field along with physicians and other healthcare practitioners.

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