Dissect the mechanisms by which CST6N137D enhances the efficacy of CAR-T cell therapy in myeloma

Funding Cycle:

2026-2027

Name:

Fenghuang (Frank) Zhan

Type of Award:

Translational Research Award

Home Institution:

University of Arkansas for Medical Sciences

Description

Our preliminary data demonstrate that CST6N137D prevents downmodulation of the CAR on the surface of CAR-T cells, maintains persistence of CAR-T cells in the body, and enhances therapeutic killing of MM cells by CAR-T cells. In this application, we will (1) determine whether CST6N137D suppresses lysosomal degradation, thereby preventing CAR downmodulation; and (2) determine the role of CST6N137D in CAR internalization and recycling. We expect to dissect the mechanisms by which CST6N137D enhances the efficacy of CAR-T cell therapy in myeloma and probably in other cancers.

Why Become a Member

The International Myeloma Society is a professional, scientific, and medical society established to bring together clinical and experimental scientists involved in the study of myeloma. The purpose of this society is to promote research, education, clinical studies (including diagnosis and treatment), workshops, conferences, and symposia on all aspects of multiple myeloma worldwide.

The IMS is a membership organization comprised of basic research scientists, and clinical investigators in the field along with physicians and other healthcare practitioners.

Stay updated on our Events

  • This field is for validation purposes and should be left unchanged.