Dissecting and appraising novel mitochondrial vulnerabilities against multiple myeloma

Basic Information

Funding Cycle : 2022-2023
Name : Simone Cenci
Type of Award : Translational Research Award
Home Institution : Ospedale San Raffaele, Milan, Italy


The study investigates mitochondria as crucial signaling hubs in cancer cells, particularly in multiple myeloma (MM), which may rely heavily on mitochondrial functions due to heightened stress experiences. The research focuses on the mitochondrial matrix protease ClpP, found to be essential for myeloma cell survival. Initial findings revealed ClpP’s role in regulating housekeeping autophagy and activating type I interferon responses, suggesting both cell-intrinsic and non-cell autonomous vulnerabilities. The project aims to dissect ClpP’s functions, resolve its structure in complex with inhibitors, and identify new mitochondrial vulnerabilities against MM using a multi-omic approach. Leveraging expertise in molecular biology, biochemistry, and genetic screening, the study seeks to uncover novel therapeutic targets for MM treatment, providing valuable insights into mitochondrial biology in cancer.

Why Become a Member

The International Myeloma Society is a professional, scientific, and medical society established to bring together clinical and experimental scientists involved in the study of myeloma. The purpose of this society is to promote research, education, clinical studies (including diagnosis and treatment), workshops, conferences, and symposia on all aspects of multiple myeloma worldwide.

The IMS is a membership organization comprised of basic research scientists, and clinical investigators in the field along with physicians and other healthcare practitioners.

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