Investigating the molecular mechanisms of microenvironment-dependent immune escape to natural killer cells in myeloma to uncover biomarkers for rational combination treatment strategie

Basic Information

Funding Cycle : 2022-2023
Name : Sara Gandfoli
Type of Award : Career Development Award
Home Institution : Hematology Research Unit, University of Helsinki, Finland
Host Institution : Centre Hospitalier Universitaire de Nantes/INSERM, France


The research project aims to understand the molecular mechanisms behind microenvironment-dependent immune escape to natural killer (NK) cells in myeloma, with the goal of identifying biomarkers for rational combination treatment strategies. Aim 1 involves validating candidate markers of NK cell resistance and investigating NK cell adaptive changes in primary myeloma samples at different disease stages using data from CRISPR screens and single-cell RNA sequencing. Aim 2 focuses on exploring the crosstalk between myeloma cells and macrophages and its impact on NK cell activation and migration, particularly in the context of monoclonal antibodies. Functional assays, RNA sequencing of the secretome, and a novel in vitro NK cell migration assay using a microfluidic MM model will be employed to elucidate the complex interactions within the myeloma microenvironment and identify potential therapeutic targets.

Why Become a Member

The International Myeloma Society is a professional, scientific, and medical society established to bring together clinical and experimental scientists involved in the study of myeloma. The purpose of this society is to promote research, education, clinical studies (including diagnosis and treatment), workshops, conferences, and symposia on all aspects of multiple myeloma worldwide.

The IMS is a membership organization comprised of basic research scientists, and clinical investigators in the field along with physicians and other healthcare practitioners.

Stay updated on our Events