Single cell dissection of autologous apheresis products to predict successful manufacturing, safe application and response to chimeric antigen receptor T-cells in newly diagnosed and relapsed myeloma

Basic Information

Funding Cycle : 2023-2024
Name : Max Merz
Type of Award : Translational Research Award
Home Institution : University of Leipzig


This project aims to dissect chimeric antigen receptor (CAR) T cell therapy in myeloma patients at a single-cell resolution to understand the factors influencing treatment success. Specific aims include analyzing factors associated with CAR T cell manufacturing success and failures, predicting CAR T cell expansion post-infusion, correlating T cell composition with side effects, identifying markers for treatment response and resistance, and comparing T cell compartments from leukapheresis and autologous stem cell products. Ultimately, the project seeks to optimize CAR T cell therapy by understanding its cellular and molecular dynamics comprehensively.

Why Become a Member

The International Myeloma Society is a professional, scientific, and medical society established to bring together clinical and experimental scientists involved in the study of myeloma. The purpose of this society is to promote research, education, clinical studies (including diagnosis and treatment), workshops, conferences, and symposia on all aspects of multiple myeloma worldwide.

The IMS is a membership organization comprised of basic research scientists, and clinical investigators in the field along with physicians and other healthcare practitioners.

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