Single cell dissection of autologous apheresis products to predict successful manufacturing, safe application and response to chimeric antigen receptor T-cells in newly diagnosed and relapsed myeloma
Basic Information
Funding Cycle :
2023-2024
Name :
Max Merz
Type of Award :
Translational Research Award
Home Institution :
University of Leipzig
Description
This project aims to dissect chimeric antigen receptor (CAR) T cell therapy in myeloma patients at a single-cell resolution to understand the factors influencing treatment success. Specific aims include analyzing factors associated with CAR T cell manufacturing success and failures, predicting CAR T cell expansion post-infusion, correlating T cell composition with side effects, identifying markers for treatment response and resistance, and comparing T cell compartments from leukapheresis and autologous stem cell products. Ultimately, the project seeks to optimize CAR T cell therapy by understanding its cellular and molecular dynamics comprehensively.
