TARGETING METABOLIC SWITCH OF HIGH-RISK MULTIPLE MYELOMA CELLS: TOWARDS THE DESIGN OF AN EXPLORATORY APPROACH FOR AN UNMET CLINICAL NEED


Basic Information

Funding Cycle : 2023-2024
Name : Michele Cea
Type of Award : Translational Research Award
Home Institution : University of Genoa

Description

Preliminary data suggest that HR landscape promotes metabolic reprogramming to sustain high-proliferation rates accompanied by a higher oxidative state compared with standard risk disease. Given these premises, this project aims to explore the potential benefit of metabolism-targeted therapy in HR-MM patients. For this purpose, we plan:
1) to evaluate multiomics (including genomics, transcriptomics, proteomics) and the resulting metabolic profile of HR-MM.
2) to study the proteomic and the resulting metabolic profile of primary MM cells obtained by HR-MM patients, performing different culture conditions in order to understand how their metabolism, signaling, cell growth and survival are influenced by the availability of carbon sources.
3) to screen a “compound library” and/or specific dietetic regimen (i.e. isocaloric ketogenic diet) to identify novel molecules targeting metabolic vulnerabilities

Why Become a Member

The International Myeloma Society is a professional, scientific, and medical society established to bring together clinical and experimental scientists involved in the study of myeloma. The purpose of this society is to promote research, education, clinical studies (including diagnosis and treatment), workshops, conferences, and symposia on all aspects of multiple myeloma worldwide.

The IMS is a membership organization comprised of basic research scientists, and clinical investigators in the field along with physicians and other healthcare practitioners.

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