Targeting the bone marrow niche in Multiple Myeloma

Basic Information

Funding Cycle : 2021-2022
Name : Tom Cupedo
Type of Award : Translational Research Award
Home Institution : Erasmus MC Cancer Center, Rotterdam, the Netherlands

Description

This research identifies MM-specific bone marrow mesenchymal stromal cells (iMSC) as crucial components of the pro-tumor microenvironment in Multiple Myeloma (MM). These iMSCs support MM cell survival and proliferation and are associated with bone marrow inflammation. Despite successful induction treatment, iMSC presence persists, potentially contributing to therapy resistance and relapse. The study aims to determine the impact of therapy on iMSC presence and function, evaluate the need for long-term maintenance treatment to eliminate iMSC, and understand the spatial distribution of iMSC and MM cells during treatment. These findings will shed light on the role of iMSC in MM therapy resistance and relapse, paving the way for targeted therapies to improve treatment outcomes.

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The International Myeloma Society is a professional, scientific, and medical society established to bring together clinical and experimental scientists involved in the study of myeloma. The purpose of this society is to promote research, education, clinical studies (including diagnosis and treatment), workshops, conferences, and symposia on all aspects of multiple myeloma worldwide.

The IMS is a membership organization comprised of basic research scientists, and clinical investigators in the field along with physicians and other healthcare practitioners.

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