Transforming Multiple Myeloma Care in Sub-Saharan Africa: Developing a Population-Specific Next Generation Sequencing Panel Based on Long-Read Whole Genome Sequencing to Enhance Treatment Outcomes in Multiple Myeloma Patients

Description

With support from the International Myeloma Society, this project aims to revolutionize the diagnosis and treatment of Multiple Myeloma (MM) in Sub-Saharan Africa. MM patients in the region often face late diagnoses and limited access to genomic tools that guide personalized care. Current treatment strategies are based on data from non-African populations, overlooking the unique genetic landscape of African MM patients.

Through this grant, we are conducting whole genome sequencing (WGS) using long-read Oxford Nanopore technology on MM samples from African patients to uncover population-specific genomic and epigenomic alterations. The findings will inform the development of a cost-effective, targeted NGS panel tailored for routine clinical use in SSA — enabling earlier detection, improved risk stratification, and more effective treatment planning.

This project not only addresses a critical gap in MM care but also contributes to my growth as a clinician-scientist. It strengthens my expertise in cancer genomics, bioinformatics, and precision diagnostics, and supports my vision to establish a sustainable genomics-based framework for blood cancer care in Africa.